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Upstream/Downstream Process Scientist – Clinical Manufacturing

Upstream/Downstream Process Scientist – Clinical Manufacturing

LocationVevey, Switzerland
Business SectorBiotechnology
Contact email
Job ref25141
Publishedabout 18 hours ago
Upstream or Downstream Process Scientist – Clinical Manufacturing

Vevey, Switzerland – Full-time, 4-month contract (possibility of extension)

Company Description
This leading biopharmaceutical company, based in Vevey, Switzerland, is at the forefront of innovation in large-scale biologics manufacturing. With a strong focus on supporting early-phase clinical programs, the site specializes in producing materials for Phase I and II clinical trials using state-of-the-art technologies and scalable bioprocessing systems.

Job Description
As an Upstream Process (USP) Scientist or Downstream Process (DSP) Scientist, you will play a vital role in supporting clinical manufacturing operations for biologics ranging from 200L to 2000L scale. In these roles, you will support the execution of pre-clinical and clinical campaigns, ensuring compliance with GMP and safety standards while contributing to the integration of new technologies and continuous improvement of bioprocesses.

Working in close collaboration with cross-functional teams - such as Production, QA, QC, and Engineering - you will be responsible for technical execution, batch documentation, deviation management, and supporting process implementation for either cell culture (USP) or purification (DSP).

Key Responsibilities:
  • Perform Electronic Batch Record (EBR) reviews using MES (Manufacturing Execution System)
  • Lead and close deviations, investigations, CAPAs, and critical control point (CCP) actions in alignment with the site’s quality plan
  • Ensure compliance with GMP, safety protocols, and internal quality standards
  • Maintain an up-to-date training plan and adhere to individual training requirements
  • Proactively report unexpected events and ensure full traceability of assigned tasks
  • Follow site EHS procedures and immediately report hazardous conditions or behaviors
  • Wear and maintain proper use of PPE and safety devices
  • Suggest improvements and actively contribute to a culture of safety and quality

Essential Requirements:
  • PhD in Chemistry, Biology, Biotechnology, or a related field with 1–2 years of industry experience OR MSc/Engineering degree with 4–5 years of relevant experience OR Technical degree with 10+ years of relevant experience in GMP manufacturing
  • Strong expertise in either:
  • USP: Fed-batch and/or perfusion cell culture
  • DSP: Chromatography, filtration, and purification operations
  • Working knowledge of GMP and BPF regulations
  • Proficiency in MES and the ability to conduct electronic batch record reviews
  • Strong communication and teamwork skills, with the ability to collaborate across departments (Production, QA, QC, Tech Ops)
  • English fluency required; French is a strong plus
    Desirable Experience:
    • Familiarity with TrackWise, SAP, LIMS, and standard office IT tools
    • Prior experience in clinical or commercial pharmaceutical production in either upstream or downstream roles
    • Demonstrated experience in deviation/CAPA management

    Additional Insights:
    • Location: Vevey, Switzerland (on-site role)
    • Contract Type: 4-month contract with strong potential for extension
    • Start Date: ASAP (flexible depending on availability)
    • Language Requirements: English required; French preferred

    Interested?
    Send your CV to Khanyi Mabena at k.mabena@panda-int.com or reach out directly at +41445514407 to learn more.