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Expert Scientist - In-Process Analytics of mRNA-Based Vaccines

Expert Scientist - In-Process Analytics of mRNA-Based Vaccines

LocationWalloon region, Belgium
Business SectorBiotechnology
Contact email
Job ref22376
Publishedabout 2 months ago

Job Title: Expert Scientist - In-Process Analytics of mRNA-Based Vaccines
Location: Belgium Walloon region
About the Job
The Cell and Viral Drug Substance team of our client is seeking a highly motivated and experienced Scientist to join the mRNA Drug Substance Development Unit and play a pivotal role in shaping the next generation of mRNA vaccine platforms for the rapid development of new vaccine candidates.
Key responsibilities:

  • Utilizing your in-depth knowledge of nucleic acid research to develop, implement, and troubleshoot in-process analytical methods (content, process- and product-related impurities) for the clinical and commercial manufacturing of mRNA.
  • Collaborating with the In-Process Analytics or Analytical Development teams to develop fit-for-purpose assays that further strengthen our process understanding.
  • Effectively liaising and coordinating with cross-functional teams (Analytical Development, In-Process Analytics, External partners) to contribute to the development and integration of our next-generation mRNA platform workflows within the broader global platform.
  • Maintaining up-to-date knowledge of best practices and advancements in mRNA technology, analytical methodologies, and regulatory guidance to support project documentation and accelerated CMC submissions.
  • Guiding and mentoring colleagues in the use and development of the assays you have created.

Essential Qualifications:

  • PhD in bio-engineering, biochemistry, biotechnology, chemistry, or equivalent, or a Master's degree in one of these fields.
  • Minimum of 3-5 years' (if PhD) or 5-8 years' (if Master's) hands-on experience in developing nucleic acid characterization methods, including fluorescent-based assays, RT-qPCR, ddPCR, hybridization technique, electrophoresis-based techniques, and HPLC/UPLC.
  • Demonstrated ability to excel in complex problem-solving through critical thinking and applying knowledge gained through formal education, experience, and sound judgment.
  • Exceptional communication skills and proven experience in effectively managing stakeholders in tight timelines.

Preferred Qualifications:

  • Experience with Quality by Design (QbD) with a demonstrated ability to develop fit-for-purpose high-throughput in-process analytics to support process development for biologics.
  • Knowledge of the relationship between mRNA structure and function.
  • Hands-on experience with advanced Next Generation Sequencing (NGS) techniques.
  • Broad understanding of analytical development workflows required for CMC support.

If you possess these qualifications and are passionate about contributing to the development of innovative mRNA-based vaccines, we encourage you to apply for this exciting opportunity.

  • Competitive salary and benefits package
  • Opportunity to work on cutting-edge drug discovery projects that have the potential to make a significant impact on human health
  • Collaborative and stimulating work environment with a strong focus on innovation
  • Chance to work with a team of talented and passionate scientists from around the world

 Interested? Contact Capucine at c.cornen@panda-int.com for more information.