Senior Bioinformatician

Location Netherlands
Discipline: Biotechnology
Job type: Permanent
Contact name: Ramon Sena

Contact email: r.sena@panda-int.com
Job ref: 10655
Published: about 1 month ago

The role:

In your role as senior Bioinformatician you guide discovery of stratification and pharmacodynamic biomarkers in support development of revolutionary new bispecific antibody therapeutics. You will have responsibilities in the Pre-clinical and Translational teams, supporting analyses of various data types: from small-scale assays to large-scale omics-type experiments, from basic research to biomarkers in clinical trials.

These will be your day-to-day tasks:

 

  • Support the design, expansion, and maintenance of pipelines for computational analyses.
  • Work with internal and external parties in project and expert teams.
  • Manage bioinformatics projects, both in-house as well as outsourced to service providers.
  • Report scientific results in reports, scientific publications, patents and regulatory documents.
  • Compute analyses described in the Biomarker Analyses Plan in support of reporting and regulatory filings.
  • Establishing analysis workflows in a dedicated system (GeneData) for e.g.

- Pre-clinical research data

- WES/ctDNA/WGS (mutational sequence data)

- RNAseq

- IHC/ISH/FISH

- Proteome data

  • Harmonizing different data types from biomarker & clinical trial data
  • Database management activities for preclinical/translational data

- Enable storage of laboratory instrument output (raw) data into preclinical database

- Low-level analyses of laboratory instrument output to preclinical database

- Manage data storage/structure in translational database

  • Providing/adapting functionality for data analysis within dedicated systems for

- antibody sequence analysis

- translational data extractions (GeneData)

  •  Responsible for technical support for preclinical laboratory data platform
  • Working closely with Translational team members to create a high quality clinical biomarker and Translational strategy.
  • You will be a member of the Translational Sciences team and reporting to the Director of Translational Sciences.

 

The main Areas of Support:

  • Automate manual processes such as:

- Analyses of pre-clinical experiments

- Generating dashboards of  translational data

  • Mine public data for pre-clinical and translational research
  • Enable meta-analysis on existing data

- E.g. on antibody DB

- E.g. on translational data in GeneData

 

Your profile:

We would like to get in touch with you if you meet the following requirements;

  • PhD degree in Molecular Biology, Biology or Biochemistry and 6+ years of experience in a similar role.
  • 3+ years’ work experience in biotech or pharma industry.
  • Profound knowledge of both molecular biology & applied bioinformatics.
  • Excellent programming skills in R and/or Python, bash) and are experienced in using relational databases.
  • Communicative and supportive attitude towards solving data analysis challenges.
  • In-depth knowledge and practical experience with bioinformatics tools and databases (transcriptomic/genomic sequence analysis, public databases like TCGA, EGA, GTEX, GEO, etc.).
  • Excellent skills in dealing with large datasets (e.g. from next generation sequencing applications and gene/protein interaction networks, Omics-type data).
  • Demonstrable experience with working with clinical data sets, including SDTM.
  • Ideally you also have experience in or knowledge of clinical (bio-)statistics and scripted results for clinical study reports (CSR).
  • You have worked within regulated environments such as ISO/GCP/GMP, and are capable of producing reproducible analyses.
  • Recognized scientific merit as documented by publications in high quality journals, references, and external presentations.
  • You are a careful planner, getting things done with enthusiasm and a clear goal in mind.
  • Excellent written and oral presentation skills in English.