Principal Scientist

Location Netherlands
Discipline: Biotechnology
Job type: Permanent
Contact name: Gemma Dozy

Contact email:
Job ref: 18999
Published: 25 days ago

Principal Scientist LNP


We are currently looking for a Principal Scientist to join our team in Limburg.

As Principal Scientist you will be a highly experienced professional and a lead scientist in the field of biotech process development, with particular experience in lipid nanoparticle formulations, product characterization techniques and tangential flow filtration (TFF). In addition you will possess good knowledge of analytical methods, Design of Experiment (DoE) studies and scale-up.

Key responsibilities:

  • Representation: act as a deputy of the team manager when needed and support the process development management.
  • Leadership: provide strong scientific, technical and regulatory leadership at project level. Lead individual scientists and lab technicians on complex projects.
  • Projects: lead multi-disciplinary matrix teams on complex projects in the area of scientific expertise. Lead problem solving and lessons learned activities.
  • Scientific tasks: design advanced experimental plans and data analysis methods, write and review high quality reports.
  • Customer interactions: develop strong customer relationships.
  • Training: lead training activities in the area of expertise.

Key requirements:

  • Lead preclinical process development research on LMP/mRNA therapeutical products.
  • In-depth knowledge with lipid nanoparticle and/or liposomes formulation development
  • Experience with analyzing data derived from process development, high-throughput screening and/or analytical characterization techniques (UV-Vis, fluorescence, SLS/DLS, particle characterization, FTIR, IR, DSC, chromatography, NMR or SAXS, etc).
  • Broad & deep expert-level experience & understanding of TFF ideally adapted to LNP/mRNA LNPs.
  • Understanding of preparation, stabilization and process scale-up of LNPs
  • Implementation of DOE studies & high-throughput screen for lipid formulations
  • Experience with different LNP generation technologies (different mixing technologies)
  • Knowledge of scale-up, technology transfer and GMP manufacturing.
  • Demonstrated ability to efficiently work in a fast paced and fluid environment .
If you are interested please contact me on 020-2044502 or email me back.